| Description | VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. |
| In vitro | Treatment (24 hour) with VH032-PEG5-C6-Cl leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1]. |
| Synonyms | HaloPROTAC 2 |
| molecular weight | 783.41 |
| Molecular formula | C38H59ClN4O9S |
| CAS | 1799506-06-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (63.82 mM) |
| References | 1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. |