| Description | VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1]. |
| In vitro | VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC 50 s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively [1]. |
| In vivo | VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models [1]. |
| molecular weight | 381.39 |
| Molecular formula | C22H15N5O2 |
| CAS | 2411174-53-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |