| Description | Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803. |
| In vitro | Peganum harmala L. (APP) 的地上部分是中国众所周知且有效的草药，常被用于治疗各种疾病，包括咳嗽和哮喘。目标：评估来自APP的生物碱部分分离的夸西酮生物碱（±）-vasicine (VAS)、deoxyvasicine (DVAS)以及由VAS合成的（±）-Vasicinone (VAO)的镇咳、祛痰和支气管扩张效果。结论：夸西酮生物碱VAS、VAO和DVAS具有显著的镇咳、祛痰和支气管扩张活动。VAS、VAO和DVAS是APP中的活性成分，可用于治疗呼吸系统疾病。 |
| molecular weight | 202.21 |
| Molecular formula | C11H10N2O2 |
| CAS | 486-64-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12 mg/mL (59.34 mM) |
| References | 1. Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L. Phytomedicine. 2015 Nov 15;22(12):1088-95. |