| Description | Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure. |
| In vitro | In ageing aorta endothelial cells, Valsartan is a synthetic antagonist of non-peptide angiotensin II type 1 receptor that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R [1].The pretreatment of valsartan can inhibit TLR2 signaling and proinflammatory cytokines. The expression of AGTR1 was up-regulated after alcohol exposure and was blocked by valsartan pretreatment[2]. |
| In vivo | In rats after MI. Heart function, Valsartan significantly attenuates the expression of TGF-β/Smad, Hif-1α and fibrosis-related protein , infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts are also significantly improved by valsartan compared with saline and hydralazine[3]. Valsartan partially reverses the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone does not exert such effects[4]. Valsartan is an effective antidepressant/antianxiety reagent and can promote the hippocampal neurogenesis and expression of BDNF.Long-term use of valsartan (5-40 mg/kg/d, oral) increases the time spent in OFT field centers and the latency to eating in NSF, reduces the fixed time of TST and FST, and increases the preference for sucrose SPT[5]. |
| Synonyms | CGP-48933 D9, 缬沙坦 D9 |
| molecular weight | 444.57 |
| Molecular formula | C24H29N5O3 |
| CAS | 1089736-73-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80. 2. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. 3. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82. 4. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9. 5. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12. |