| Description | VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects. |
| In vitro | 在HL-60细胞中，VAF347增强了维甲酸诱导的AhR、Lyn、Vav1和c-Cbl的表达，以及p47phox。信号体中几个伙伴的相互作用似乎得到增强：Fgr与c-Cbl、CD38和pS259c-Raf发生相互作用，AhR与c-Cbl和Lyn发生相互作用[1]。VAF347增强了维甲酸诱导的细胞周期阻滞[1]。 |
| In vivo | AhR缺失的小鼠对VAF347阻断体内过敏性肺炎的能力具有抵抗性[2]。 |
| Synonyms | 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺 |
| molecular weight | 349.74 |
| Molecular formula | C17H11ClF3N3 |
| CAS | 574759-62-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 17.85 mg/mL (51.05 mM), Sonication is recommended. |
| References | 1. Ibabao CN, et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr 8;5:308-18. 2. B Paige Lawrence, et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15;112(4):1158-65. |