| Description | Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections. |
| In vitro | β-内酰胺酶抑制剂 vaborbactam 也能与假单胞菌 PBP3 形成酰酶复合物。vaborbactam 能够抑制 PBP3（IC50为 262 μM），并且其与 PBP3 的结合可使蛋白质的热稳定性增加约 2°C[1]。 |
| In vivo | 在中性粒细胞减少性小鼠大腿感染模型中，单独使用 100 mg/kg 美罗培南以及与不同剂量的 vaborbactam 联合对抗肺炎克雷伯菌，结果显示腹膜内注射 300 mg/kg 美罗培南与 50 mg/kg 的vaborbactam 合并与未处理对照组相比，对细菌计数产生了最大的减少[2]。 |
| Synonyms | RPX7009 |
| molecular weight | 297.14 |
| Molecular formula | C12H16BNO5S |
| CAS | 1360457-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 2 mg/mL (6.73 mM), Sonication is recommended. |
| References | 1. Kumar V,et al. Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3. PLoS One. 2021 Oct 15;16(10):e0258359. 2. Sabet M,et al. Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01446-17. |