| Description | Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities. |
| In vitro | Uvaol 通过抑制心脏肌成纤维细胞中由血管紧张素II诱导的I型胶原和galectin 3水平来发挥作用[1]。此外，Uvaol还能减轻小鼠卵清蛋白诱导的过敏反应中的胸膜炎和嗜酸性炎症[2]。 |
| molecular weight | 442.72 |
| Molecular formula | C30H50O2 |
| CAS | 545-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 8 mg/mL (18.07 mM), Sonication and heating to 60℃ are recommended. DMSO: 1.5 mg/mL (3.39 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Martín R, et al. DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy. PLoS One. 2012;7(7):e41545. 2. Agra LC, et al. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. Eur J Pharmacol. 2016 Jun 5;780:232-42. |