| Description | USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1]. |
| In vitro | USP7-IN-12（化合物1）在72小时的处理后，展现出了对RS4;11细胞线具有的抗增殖效果，其半抑制浓度（IC50）值为69.5纳摩尔（nM）[1]。 |
| In vivo | USP7-IN-12（5 mg/kg；口服）在雄性SD大鼠体内表现出优异的药代动力学特性，其中半衰期（T1/2）为3.68小时，达到最大浓度时间（Tmax）为3.33小时，最大浓度（Cmax）为330 ng/mL，AUC0-inf为2014 hr*ng/mL[1]。 |
| Target activity | USP7:3.67 nM |
| molecular weight | 551.07 |
| Molecular formula | C29H28ClFN4O2S |
| CAS | 2763698-01-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |