| Description | Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, has an inhibitory effect on lipid peroxidation and is associated with the pathogenesis of gout joint disease and the formation of calcium oxalate stones. |
| In vitro | Uric acid, when administered at a concentration of 400 μM for 48 hours, offers protection to Caco-2 cells by preventing indomethacin-induced lipid peroxidation [2]. Furthermore, co-treatment of cells with indomethacin and uric acid sodium (200 μM indomethacin plus 400 μM uric acid; 24 hours) significantly reduces reactive oxygen species (ROS) levels compared to cells treated with indomethacin alone. Additionally, cell viability in Caco-2 cells exposed to both indomethacin and uric acid sodium (200 μM indomethacin plus 400 μM uric acid; 24 hours) is higher compared to cells treated solely with indomethacin. The protective effect of uric acid sodium on indomethacin-induced changes in intestinal cells is attributed to its antioxidant activity [2]. |
| In vivo | 经口给予Uric acid sodium ，剂量为250 mg/kg，对吲哚美辛引起的小肠病变具有积极作用。它能改善由吲哚美辛所导致的小肠病变。Uric acid sodium 的口服治疗有助于减少小鼠吲哚美辛引起的小肠病变模型中空肠的ROS积累[2]。 |
| Synonyms | 尿酸钠 |
| molecular weight | 190.09 |
| Molecular formula | C5H3N4NaO3 |
| CAS | 1198-77-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.8 mg/mL (14.8 mM), when pH is adjusted to 4 with HCl. Sonication and heating to 60℃ are recommended. |
| References | 1. Wang Q, , et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375. |