| Description | UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. |
| In vitro | UPF 1069 是一种选择性的 PARP2 抑制剂，其 IC50 值为0.3 μM，同时对 PARP1 的抑制作用较弱，IC50 值为8 μM。[1] |
| In vivo | In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1] |
| Target activity | PARP2:0.3 μM |
| molecular weight | 279.29 |
| Molecular formula | C17H13NO3 |
| CAS | 1048371-03-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.9 mg/mL (100 mM) |
| References | 1. Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862. |