PeptideDB

UNIL-088

CAS No.: 473545-11-8

UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is graft
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Description UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. UNIL-088 is more stable at pH 5 than at pH 7 with conversion rate constant of 3.2 x 10(-3) and 26.0 x 10(-3)days(-1), respectively.
Synonyms UNIL 088
molecular weight 1570.87
Molecular formula C73H128N13O22P
CAS 473545-11-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Lallemand, F.; Varesio, E.; Felt-Baeyens, O.; Bossy, Leila; Hopfgartner, G.; Gurny, R. Biological conversion of a water-​soluble prodrug of cyclosporine A. European Journal of Pharmaceutics and Biopharmaceutics (2007), 67(2), 555-561. 2. Lallemand, F.; Behar-Cohen, F.; Felt-Baeyens, O.; Rudaz, S.; Furrer, P.; Besseghir, K.; Dumont, J.-M.; Gurny, R. Cyclosporine A prodrug for topical delivery to the eye. Ocular Pharmacology and Therapeutics--ISOPT, Proceedings of the International Symposium, 5th, Monte Carlo, Monaco, Mar. 11-14, 2004 (2004), 105-109. 3. Lallemand, Frederic; Perottet, Philippe; Felt-Baeyens, Olivia; Kloeti, Werner; Philippoz, Florence; Marfurt, Judith; Besseghir, Kamel; Gurny, RobertA water-​soluble prodrug of cyclosporine A for ocular application: A stability study. European Journal of Pharmaceutical Sciences (2005), 26(1), 124-129. 4. Lallemand, F.; Furrer, P.; Felt-Baeyens, O.; Gex-Fabry, M.; Dumont, J.-M.; Besseghir, K.; Gurny, R. A novel water-​soluble cyclosporine A prodrug: ocular tolerance and in vivo kinetics. International Journal of Pharmaceutics (2005), 295(1-2), 7-14.