| Description | UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 μM. It impedes 53BP1's recruitment to DNA double-strand breaks (DSBs), maintaining the protein's autoinhibited state within cells [1]. |
| In vitro | 与 WT 53BP1 TT 不同，53BP1 TT-PN 并不与 UNC3474 发生相互作用[1]。 |
| molecular weight | 276.42 |
| Molecular formula | C17H28N2O |
| CAS | 1648707-79-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |