| Description | UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand. |
| In vitro | UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1]. |
| Synonyms | UNC2170 Maleate, UNC-2170 Maleate, UNC 2170 Maleate |
| molecular weight | 313.23 |
| Molecular formula | C14H21BrN2O |
| CAS | 1648707-58-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (191.55 mM), Sonication is recommended. Methanol: 125 mg/mL (399.07 mM), Sonication is recommended. |
| References | 1. Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28. PubMed PMID: 25590533; PubMed Central PMCID: PMC4402254. |