| Description | Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism. |
| In vitro | Umbellulone selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells. |
| In vivo | In Trpa1+/+ mice, Umbellulone (50–250?nM/5ul) causes an acute nocioceptive response in a dose-dependent manner . Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner. |
| molecular weight | 150.22 |
| Molecular formula | C10H14O |
| CAS | 546-78-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Nassini R, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012 Feb;135(Pt 2):376-90. |