| Description | UK51656 is an antagonist of calcium (IC50: 4 nM). |
| In vivo | The elimination half-life of UK51656 is 4.7 hours, which is consistent with the duration of its effect in anesthetized dogs. The effect of UK51656 on coronary vascular resistance is very long, more than 5 hours. |
| Target activity | Ca2+:4 nM |
| molecular weight | 465.93 |
| Molecular formula | C22H28ClN3O6 |
| CAS | 88150-59-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91. |