| Description | UK-500001 is a potent PDE4 inhibitor with robust anti-inflammatory activity. |
| Synonyms | UK500001, UK 500,001, UK-500,001, UK500,001 |
| molecular weight | 499.48 |
| Molecular formula | C26H24F3N3O4 |
| CAS | 582332-31-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Moretto N, Caruso P, Bosco R, Marchini G, Pastore F, Armani E, Amari G, Rizzi A, Ghidini E, De Fanti R, Capaldi C, Carzaniga L, Hirsch E, Buccellati C, Sala A, Carnini C, Patacchini R, Delcanale M, Civelli M, Villetti G, Facchinetti F. CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. doi: 10.1124/jpet.114.220541. PubMed PMID: 25576075. 2. Vestbo J, Tan L, Atkinson G, Ward J; UK-500,001 Global Study Team.. A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur Respir J. 2009 May;33(5):1039-44. doi: 10.1183/09031936.00068908. PubMed PMID: 19213793. |