| Description | UK-124114 (Selamectin) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition. |
| In vivo | A single administration of 6 mg/kg topical selamectin given every two months could effectively prevent B. malayi infection.?Application of topical selamectin twice a year could block circulating microfilariae.?Since there are no treatment guidelines currently available for lymphatic filarial infection in cats, the data obtained from this study could be used to guide the management of brugian lymphatic filarial infection in reservoir cats[3]. |
| Synonyms | UNII-A2669OWX9N, 西拉菌素, Selamectin |
| molecular weight | 769.96 |
| Molecular formula | C43H63NO11 |
| CAS | 165108-07-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (64.94 mM) |
| References | 1. Holden-Dye, L. , et al. Anthelmintic drugs and nematicides: Studies in Caenorhabditis elegans. WormBook 16, (2014). 2. Michael, B.,et al. Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay. Journal of Parasitology 87(3), 692-696 (2001). 3. Sarasombath P T , Thammapalo S , Loymek S , et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions[J]. Parasitology Research, 2019, 118(4):1289-1297. |