| Description | UC-857993, a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), effectively suppresses catalytic activity. In addition to inhibiting ERK and Ras activation, it also hampers the growth of mouse embryonic fibroblasts (MEFs). |
| In vitro | Imidacloprid (0, 10, and 20 μM ; 4-6 days) can reduce insulin-stimulated glucose uptake in adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12) cell culture models. Treatment with imidacloprid inhibits phosphorylation of protein kinase B (AKT) and ribosomal S6 kinase (S6K).[3] |
| In vivo | Imidacloprid(0, 5, 10, 20 mg/kg/day ; oral ; female rats) shows mild pathological changes in the brain, liver, and kidneys of rats.[4] |
| molecular weight | 403.9 |
| Molecular formula | C25H22ClNO2 |
| CAS | 487001-04-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |