| Description | UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM). |
| In vitro | UC-112 在低至1 μM的浓度下，有效抑制P糖蛋白(P-gp)过表达的多药耐药癌细胞生长，强烈激活caspase-3/7和caspase-9的活性，并选择性下调survivin水平。与已知的蛋白酶体抑制剂Z-Leu-Leu-Leu-CHO共孵育时，survivin的抑制得到挽救，这与UC-112预期的作用机制一致[1]。 |
| In vivo | UC-112在体内A375人类黑色素瘤异种移植模型中，强效抑制肿瘤生长，并降低X染色体连锁IAP及survivin水平[1]。 |
| molecular weight | 348.44 |
| Molecular formula | C22H24N2O2 |
| CAS | 383392-66-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 8 mg/mL (22.96 mM), Sonication is recommended. |
| References | 1. Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29. |