| Description | UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85). |
| In vivo | In Freund's adjuvant (CFA)-induced adjuvant arthritis (AA) rat model, UbcH5c-IN-1 (5 and 20 mg/kg, p.o., daily, 10-20 days) treatment results in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group. |
| Target activity | E2 UbcH5c:(kd)283 nM |
| molecular weight | 413.3 |
| Molecular formula | C22H21BrO3 |
| CAS | 2123480-72-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chen H, et al. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives. J Med Chem. 2017 Aug 24;60(16):6828-6852. |