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U-74389G

CAS No.: 153190-29-5

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion in
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Description U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4]
Synonyms U-74389G, Methylated Tirilazad
molecular weight 726.919
Molecular formula C41H54N6O6
CAS 153190-29-5
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility DMSO: 35 mg/mL DMF: 36 mg/mL Ethanol: 1 mg/mL
References 1. Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63, 202-208 (1997). 2. Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. Journal of Surgical Research 66, 131-137 (1996). 3. Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacological Research 34, 25-31 (1996). 4. Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63, 495-500 (1997).