| Description | TZ4M, a 2,4-thiazolidinedione (TZD)-based anti-ADV agent, exhibits neuroprotective effects and acetylcholinesterase (AChE) inhibition in human plasma. It enhances memory and cognitive function in adult rats within a scopolamine-induced Alzheimer-type model [1]. |
| In vivo | 在大鼠模型中，TZ4M（2、3 mg/kg；腹腔注射；每日一次，连续8天）能够抑制由东莨菪碱（3 mg/kg；腹腔注射）引发的海马神经元损伤以及海马及皮层区域DG和CA1神经元中的蛋白质凋亡，且可增加上述区域内mAChR M1的表达量[1]。通过CBligand-BBB预测，TZ4M可穿透血脑屏障(BBB)，这一特性对于AChE抑制作用是必需的[1]。 |
| molecular weight | 353.39 |
| Molecular formula | C19H15NO4S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |