| Description | Tyroserleutide (YSL), isolated from the degradation products of porcine spleen, is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo.Tyroserleutide inhibits the growth and metastasis of human hepatocellular carcinoma (HCC). |
| In vitro | Tyroserleutide (YSL) 具有免疫调节作用，例如增强刀豆蛋白A (ConA) 诱导的小鼠脾脏淋巴细胞增殖、小鼠腹腔巨噬细胞的吞噬作用以及自然杀伤 (NK) 细胞的活性[1]。作为一种免疫学治疗三肽，Tyroserleutide (YSL) 可通过下调Bcl-2和cyclin D1表达来促进肝癌细胞 (H22) 的凋亡[2]。Tyroserleutide 是诱导肝脏肿瘤细胞凋亡的理想选择[2]。它抑制肿瘤生长且不会对主要器官造成严重毒性。Tyroserleutide 还能抑制肿瘤细胞迁移[2]。 |
| molecular weight | 381.42 |
| Molecular formula | C18H27N3O6 |
| CAS | 138168-48-6 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: Soluble |
| References | 1. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95. |