| Description | Tyropeptin A-4 is used as a proteasome inhibitor. |
| Synonyms | TP 101, TP-101, TP101 |
| molecular weight | 551.67 |
| Molecular formula | C31H41N3O6 |
| CAS | 688737-89-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, Yamori T, Masuda T, Nomoto A. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors. Cancer Sci. 2014 Dec;105(12):1609-15. doi: 10.1111/cas.12542. Epub 2014 Oct 21. PubMed PMID: 25251038; PubMed Central PMCID: PMC4317970. 2. Watanabe T, Abe H, Momose I, Takahashi Y, Ikeda D, Akamatsu Y. Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5839-42. doi: 10.1016/j.bmcl.2010.07.122. Epub 2010 Aug 1. PubMed PMID: 20727746. 3. Steverding D, Pemberton AJ, Royle H, Spackman RW, Rivett AJ. Evaluation of the anti-trypanosomal activity of tyropeptin A. Planta Med. 2006 Jun;72(8):761-3. Epub 2006 May 29. PubMed PMID: 16732530. 4. Momose I, Umezawa Y, Hirosawa S, Iinuma H, Ikeda D. Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1867-71. PubMed PMID: 15780623. |