| Description | Tylosin (Tylosine) is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans. |
| In vivo | Tylosin 及其磷酸盐和酒石酸盐用于猪、牛和家禽，治疗对Tylosin 敏感的生物体引起的感染。犊牛可通过乳汁口服，剂量为 40 毫克体重（bw）；牛可通过肌肉注射，剂量为 4-10 毫克/千克体重。Tylosin可按每公斤体重 25 毫克的剂量在饮用水中添加，按每公斤体重 3-7 毫克的剂量在饲料中添加，或按每公斤体重 2-10 毫克的剂量进行肌肉注射。Tylosin 用于家禽饮用水中，剂量相当于 75 毫克/千克体重。它主要用于治疗鸡的慢性呼吸道疾病和由五倍子支原体引起的火鸡传染性鼻炎。 |
| Synonyms | Fradizine, Tylosin A, 泰乐菌素, Tylosine, Tylocine |
| molecular weight | 916.1 |
| Molecular formula | C46H77NO17 |
| CAS | 1401-69-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 91 mg/mL (99.3 mM) |
| References | 1. Entorf M, et al. Tylosin susceptibility of staphylococci from bovine mastitis. Vet Microbiol. 2014 Jul 16;171(3-4):368-73. 2. Pilcher CM, et al. Impact of tylosin phosphate and distillers dried grains with solubles on energy and nutrient digestibility and flow through the gastrointestinal tract in growing pigs. J Anim Sci. 2013 Dec;91(12):5687-95. |