| Description | TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively). |
| In vivo | TY-51469 inhibits the accumulation of neutrophils in the lung and decreases silica-induced pulmonary fibrosis in mice. TY-51469 displays 100% stability in rat plasma at 40°C for as long as 1 hour [1]. |
| Target activity | Chymase (human):0.7 nM, Simian chymase:0.4 nM |
| molecular weight | 526.6 |
| Molecular formula | C20H15FN2O6S4 |
| CAS | 603987-59-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (85.45 mM), Sonication is recommended. |
| References | 1. Takato H, et al. The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. Expert Opinion on Therapeutic Targets Volume 15, 2011 - Issue 4. |