| Description | TX2-121-1 targets HER3 for proteasome-mediated degradation to inhibit HER3-dependent signalling and growth. |
| Synonyms | TX 21211, TX 2-121-1 |
| molecular weight | 716.91 |
| Molecular formula | C42H52N8O3 |
| CAS | 1603845-42-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Development of small molecules targeting the pseudokinase Her3. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3382-9. doi: 10.1016/j.bmcl.2015.04.103. Epub 2015 May 11. PubMed PMID: 26094118; PubMed Central PMCID: PMC4633287. 2. Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12. doi: 10.1038/nchembio.1658. Epub 2014 Oct 19. PubMed PMID: 25326665; PubMed Central PMCID: PMC4232461. |