| Description | Tween 80 is a nonionic surfactant and emulsifier that reduces bacterial adherence and inhibits biofilm formation. Tween 80 is widely used as a co-solvent in pharmacology experiments because of its ability to enhance the solubility of compounds in the aqueous phase. |
| In vitro | 方法：金黄色葡萄球菌 (S. aureus)、李斯特菌 (L. monocytogenes) 和荧光假单胞菌 (P. fluorescens) 用 Tween 80 (0.1% (v/v) in TSB) 处理，通过每 20 min 测量 OD600 的光密度来记录生长曲线。结果：Tween 80 的增加了 S. aureus 的生长速率。Tween 80 不影响 L.monocytogenes的生长。P. fluorescens Tween 80组的生长速率最初高于对照组，但随后再次下降，最大 OD 显著低于对照。[1] |
| In vivo | 方法：为研究溶剂对小鼠运动活性影响，将 Tween-80/Tween-20 (4%-64% (v/v) in saline) 单次腹腔注射给 (BALB/c * DBA/2)F1 小鼠，在给药后监测运动机能活动 12 h。结果：Tween-80 在浓度为 32% 时显著降低小鼠运动活性。Tween-20 在浓度为 16% 时显著降低小鼠运动活性。[2]方法：为检测体内抗肿瘤活性，将 ATL (15-30 mg/kg in 5% DMSO + 30% PEG300 + 10% Tween 80 + 55% PBS) 腹腔注射给携带人甲状腺癌肿瘤 8505C 的 BALB/c小鼠，每天一次，持续九周。结果：ATL 抑制 8505C 细胞异种移植物的体内生长。[3] |
| Synonyms | 吐温 80 |
| molecular weight | N/A |
| CAS | 9005-65-6 |
| Storage | store at 4°C | Shipping with blue ice. |
| References | 1. Nielsen CK, et al. Effects of Tween 80 on Growth and Biofilm Formation in Laboratory Media. Front Microbiol. 2016 Nov 22;7:1878. 2. Castro CA, et al. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6. 3. Hu Y, et al. Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway. Phytomedicine. 2023 Jan;108:154528. |
| Citations | 1. Hu Y, Wen Q, Cai Y, et al. Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway. Phytomedicine. 2022: 154528. 2. Yang D, Fan Y, Xiong M, et al.Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1.EMBO reports.2023: e56128. 3. Guo Y, Zhu L, Duan Y, et al.Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission.Cell Death & Disease.2024, 15(2): 125. |