| Description | Tuna AI acetate is an inhibitor of angiotensin-converting enzyme (ACE) in non-competitive manner derived from tuna muscle. |
| In vitro | Tuna AI acetate inhibited rabbit lung ACE non-competitively with Ki values of 1.7 and 5.7 microM with substrates, hippuryl-L-histidyl-L-leucine and angiotensin I, respectively. Tuna AI acetate (5.3 microM) also doubled the effect of bradykinin in the contraction of isolated guinea pig ileum[1]. |
| Target activity | Hippuryl-L-histidyl-L-leucine:1.7 μM(rabbit lung ACE), Ang I:5.7 μM(rabbit lung ACE) |
| molecular weight | 1013.1 |
| Molecular formula | C46H68N12O14 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (22.21 mM) |
| References | 1. Kohama Y, et al. Biological properties of angiotensin-converting enzyme inhibitor derived from tuna muscle. J Pharmacobiodyn. 1989 Sep;12(9):566-71. |