| Description | Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs. |
| In vitro | 53BP1 becomes hyperphosphorylated and rapidly relocates to the sites of DNA strand breaks in response to ionizing radiation. 53BP1 foci formation is reduced in ATM-deficient cells and can be inhibited by wortmannin in ATM wild-type cells. Moreover, radiation-induced hyperphosphorylation of 53BP1 is absent in cells treated with wortmannin, as well as in ATM-deficient cells. 53BP1 participates in DNA damage–signaling pathways and is regulated by ATM after γ-radiation6. |
| molecular weight | 1242.38 |
| Molecular formula | C57H87N13O18 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: ≥124.2 mg/mL |
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
CAS No.:
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts w
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