| Description | Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase as well as induces apoptosis. Tubulin polymerization-IN-22 is an inhibitor of tubulin polymerization (IC 50 = 8.1 μM) [1]. |
| In vitro | Tubulin polymerization-IN-22 (Compound 4u) shows antiproliferative activity against human breast cancer cell line (MCF-7) with an IC50 of 1.47 μM [1]. Tubulin polymerization-IN-22 (Compound 4u) is a tubulin polymerization inhibitor by targeting the Colchicine binding site [1]. |
| molecular weight | 308.33 |
| Molecular formula | C19H16O4 |
| CAS | 2493052-22-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |