| Description | Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cell lung, renal, prostate, and breast cancers [1]. |
| In vitro | Tubulin polymerization-IN-2 (compound 2b) shows anti-cancer activity against epidermal carcinoma and breast carcinoma with IC 50 s of 2.3 μM (KB) and 2.2 μM (BT-549), respectively [1]. Tubulin polymerization-IN-2 (0.342 μM; 24 h) inhibits DNA synthesis or repair, arrests cell cycle at S phase in MCF-7 cells [1]. Tubulin polymerization-IN-2 (0.342 μM; 24 h) induces cell apoptosis by decreasing Bax, APAF-1, and caspase-3 expression and increasing BCL-2 mRNA abundance [1]. Tubulin polymerization-IN-2 (0.01, 0.1, 1, 10 μM; 1 h) has strong interactions on β-tubulin polymerization, with K i value of 0.09 μM [1]. |
| molecular weight | 314.29 |
| Molecular formula | C17H12F2N2O2 |
| CAS | 2873399-22-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |