| Description | Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM). |
| In vitro | Tuberculosis inhibitor 1 is selective over other parasites (T. cruzi EC50 8120 nM, P. falciparum EC50 3624 nM). |
| Target activity | T. b. brucei:(EC50)5 nM |
| molecular weight | 563.69 |
| Molecular formula | C34H37N5O3 |
| CAS | 2230810-28-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ferrigno F, et al. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitorsof Trypanosoma brucei growth in vitro. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3689-3692. |