| Description | TSR-033 is a human IgG4 antibody with high affinity for LAG-3 (lymphocyte activation gene-3), a co-receptor linked to diminished T cell activity, frequently co-expressed with PD-1. It bolsters T cell function and augments PD-1 inhibition both in vitro and in vivo, demonstrating anti-tumor activity [1]. |
| In vitro | TSR-033（浓度范围0.01-1000 nmol/L，处理时间48小时）能够提升原代人类CD4 T细胞与树突状细胞的IL2产量，并增强T细胞效应器功能[1]。 |
| In vivo | "TSR-033(i.p.,10 mg/kg,两次每周,共40天)在A549 HuNOG-EXL NSCLC小鼠模型中表现出对肿瘤生长具有中等抑制效果，单独使用时治疗结束时的肿瘤生长抑制率(TGI)为23%；与TSR-042联合应用时，显示出叠加式抑制作用，治疗结束时TGI可达45% [1]。" |
| molecular weight | N/A |
| CAS | 2225940-96-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years |