| Description | N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide (TS-011) is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor. |
| In vivo | TS-011以0.3 mg/kg的剂量可以抑制再灌注后1小时与7小时血流速度的下降（P<0.001），并在24小时后抑制血流速度的增加（P<0.01）。同样剂量的TS-011还可减少近40%的梗死体积（P<0.05）。TS-011能够保护微血管灌注区，防止受到对照组小鼠处理中观察到的损失[1]。在9只出现延迟性血管痉挛的犬只中，通过静脉注射TS-011（1 mg/kg），有效地阻断20-HETE的合成，显著增加基底动脉的直径39%[2]。 |
| Synonyms | N-(3-氯-4-吗啉代苯基)-N'-羟基甲脒, TS-011 |
| molecular weight | 255.7 |
| Molecular formula | C11H14ClN3O2 |
| CAS | 339071-18-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 240 mg/mL (938.60 mM), Sonication is recommended. |
| References | 1. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402. 2. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1350-4. |