| Description | Trimethobenzamide hydrochloride (Ro 2-9578) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. |
| In vitro | Trimethobenzamide是一种（非苯噻嗪）类苯甲酰胺抗呕吐化合物，通过中枢作用阻断D2受体，从而通过阻断呕吐中枢的呕吐冲动来抑制延髓化学感受器触发区。 |
| In vivo | Trimethobenzamide的口服生物利用度为60%至100%。口服后约45分钟达到血药浓度峰值；肌肉内（I.M.）给药后约30分钟达到峰值。 |
| Synonyms | 盐酸三甲氧苯酰胺, Ro 2-9578, Tribenzagan Hydrochloride |
| molecular weight | 424.92 |
| Molecular formula | C21H29ClN2O5 |
| CAS | 554-92-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (235.34 mM) |
| References | 1. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. |