| Description | Triflubazam has a wide range of biological activities that can affect sleep and can be used to treat anxiety syndromes and psychological disorders. |
| In vivo | Triflubazam（20mg和40mg）缩短了第三阶段的潜伏期，并减少了清醒（第0阶段）和嗜睡（第1阶段）的活动时长。[1] Triflubazam（20mg）降低了第1阶段的睡眠比例（P小于0.05）。[1] Triflubazam（40mg）摄入后，减少了早晨的清醒时间（P小于0.05）。[1] |
| molecular weight | 334.29 |
| Molecular formula | C17H13F3N2O2 |
| CAS | 22365-40-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (179.48 mM) |
| References | 1. Nicholson AN, et al. Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man. Br J Clin Pharmacol. 1977 ; 4(5):567-572. 2. Alton KB, et al. Comparative biotransformation of triflubazam in rats, dogs, and monkeys. Drug Metab Dispos. 1975 ; 3(6):445-452. 3. Huettemann RE, et al. High-pressure liquid chromatographic analysis of triflubazam and its metabolites in human and animal blood and urine. J Pharm Sci. 1975 ; 64(8):1339-1342. 4. Alton KB, et al. Biotransformation of a 1,5-benzodiazepine, triflubazam, by man. Drug Metab Dispos. 1975 ; 3(5):352-360. |