| Description | Trientine-2HCl (Trien), a chelating agent, is used to treat Wilson's disease by binding up and removing copper in the body. Trientine can also be used as a chelating agent for copper in hepatolenticular degeneration, as a stabilizer for epoxy resins, and as ampholyte for isoelectric focusing. |
| Synonyms | Triethylenetetramine, Trientine HCl, Trientine, 盐酸三乙烯四胺, Triethylene tetramine, TETA, Trien |
| molecular weight | 219.15 |
| Molecular formula | C6H20Cl2N4 |
| CAS | 38260-01-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 27.5 mg/ml (125.48 mM) |
| References | 1. Ala A, Aliu E, Schilsky ML. Prospective Pilot Study of a Single Daily Dosage of Trientine for the Treatment of Wilson Disease. Dig Dis Sci. 2015 Jan 21. [Epub ahead of print] PubMed PMID: 25605552. 2. Chandok N, Roberts EA. The trientine crisis in Canada: a call to advocacy. Can J Gastroenterol Hepatol. 2014 Apr;28(4):184. PubMed PMID: 24729990; PubMed Central PMCID: PMC4071922. 3. Fu S, Hou MM, Wheler J, Hong D, Naing A, Tsimberidou A, Janku F, Zinner R, Piha-Paul S, Falchook G, Kuo MT, Kurzrock R. Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies. Invest New Drugs. 2014 Jun;32(3):465-72. doi: 10.1007/s10637-013-0051-8. Epub 2013 Dec 5. PubMed PMID: 24306314. 4. Rezaei A, Heidarian E. Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats. Indian J Exp Biol. 2013 Aug;51(8):646-52. PubMed PMID: 24228388. |