| Description | Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. |
| Synonyms | Naqua, Metahydrin, 三氯噻嗪, Trichlormetazid |
| molecular weight | 380.66 |
| Molecular formula | C8H8Cl3N3O4S2 |
| CAS | 133-67-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (131.35 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Temperini C, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. |