| Description | TREM2 agonist-2 (I-192) is an orally active and potent myeloid triggered receptor 2 (TREM2) agonist for the study of neurodegenerative diseases. |
| In vitro | TREM2 agonist-2（0-100μM;16小时）处理通过细胞活力测定能够激活 HEK293 细胞中的 hTREM2，其 EC50 值小于0.05 μM[1]。 |
| In vivo | TREM2 agonist-2（50mg/kg;每天两次;一天；口服强饲），结果表明 TREM2 靶点能与小胶质细胞结合[1]。 |
| molecular weight | 451.92 |
| Molecular formula | C24H23ClFN5O |
| CAS | 2738485-98-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45.19 mg/mL (100 mM）, Sonication is recommended. |
| References | 1. InventorLara C. CZABANIUKT，et al.Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use:WO2021226629A1. |