| Description | Transcrocetin meglumine salt is a natural product isolated from saffron (Crocus sativus L.) and is a high-affinity antagonist of the NMDA receptor. |
| In vitro | Transcrocetin (trans-Crocetin) shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.Cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability. |
| Synonyms | trans-Crocetin meglumine salt |
| molecular weight | 718.83 |
| Molecular formula | C34H58N2O14 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract ( |