| Description | TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. |
| In vitro | TP0586532是UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC)的抑制剂，其IC50值为0.101 μM[1]。 |
| Target activity | LpxC:0.101 μM |
| molecular weight | 460.52 |
| Molecular formula | C26H28N4O4 |
| CAS | 2427584-96-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (108.57 mM) |
| References | 1. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964. |