| Description | Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1]. |
| In vitro | Topsalysin在19 pM至10 nM浓度范围内，48小时处理LNCaP、PC3、DU145和TSU细胞株后，展现出对前列腺特异性抗原(PSA)具依赖性的毒性作用[1]。 |
| In vivo | Topsalysin（肿瘤内注射；1-10μg/鼠标；单次剂量）有效抑制小鼠肿瘤生长[1]。通过腹腔注射单次剂量的Topsalysin（0.35、4.1、25.8 μg/kg, 25 μL）可在食蟹猴前列腺注射部位诱导高达50%的细胞死亡[1]。 |
| Synonyms | PRX-302 |
| molecular weight | N/A |
| CAS | 917121-25-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |