| Description | TOK-8801 is a synthetic dihydroimidazole thiazole carboxamide with immunomodulatory activity that eliminates the stimulatory effects of antibody production by removing T cells. |
| In vitro | TOK-8801 在体外浓度为 10（-7）-10（-5）M 时增强了小鼠脾细胞和胸腺细胞的抗羊红细胞（SRBC）斑块形成细胞（PFC）反应和有丝分裂原诱导的增殖反应，而 LMS 在10（-4）M 时增强了这些反应[1]。 |
| In vivo | TOK-8801 （0.5 mg/kg， p.o.） 抑制了正常小鼠体内抗 SRBC PFC 的产生，但恢复了约束应激小鼠中抑制抗体的产生[1]。 |
| molecular weight | 315.43 |
| Molecular formula | C17H21N3OS |
| CAS | 105963-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Fujiwara M,et al. Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2- carboxamide). Jpn J Pharmacol. 1989 Dec;51(4):549-54. 2. Shibata K,et al. Immunomodulatory effect of a newly synthesized compound, TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo [2,1-b]thiazole-2-carboxamide) on antibody production in vivo and delayed-type hypersensitivity in mice. Int J Immunopharmacol. 1990;12(5):497-502. |