| Description | TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM. By binding to TNF-α, it impedes TNF-α-induced caspase activation and the NF-κB signaling pathway. Additionally, it suppresses the phosphorylation of IκBα and the nuclear migration of NF-κB p65. This compound is utilized in the study of TNF-α-mediated autoimmune diseases [1]. |
| molecular weight | 422.47 |
| Molecular formula | C24H26N2O5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |