| Description | TN-871 is a potassium and calcium channel antagonist. TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh. |
| Synonyms | TN-871 dihydrochloride, TN871, TN 871, TN-871 |
| molecular weight | 387.35 |
| Molecular formula | C19H28Cl2N2O2 |
| CAS | 118848-33-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Katayama Y, Morita K, Hirai K. Concentration-dependent actions of a new indene derivative, TN-871, in the enteric nervous system. Eur J Pharmacol. 1998 Jan 26;342(2-3):167-75. PubMed PMID: 9548382. 2. Shen YL, Hirai K, Katayama Y. Effects of an indene-derivative, TN-871, on synaptic transmission in a sympathetic ganglion: presynaptic actions on neurotransmitter release. Bull Tokyo Med Dent Univ. 1995 Mar;42(1):19-29. PubMed PMID: 7895315. |