| Description | TMP-778 is a selective inverse agonist of RORγt. |
| molecular weight | 494.58 |
| Molecular formula | C31H30N2O4 |
| CAS | 1422171-08-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (111.2 mM) |
| References | 1. Jill Skepner, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75. 2. Sheng Xiao, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity.2014 Apr 17;40(4):477-89. |