| Description | TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholesterol in rats and hamsters. |
| molecular weight | 437.87 |
| Molecular formula | C24H18ClF2N3O |
| CAS | 128831-46-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 10 mg/mL DMSO: 30 mg/mL |
| References | 1. Sugiyama Y, et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis. 1995 Feb;113(1):71-8. 2. Sugiyama Y,et al. TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters. Atherosclerosis. 1995 Nov;118(1):145-53. |