| Description | TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. |
| In vitro | 在THP-1细胞和人类单核细胞中，使用siRNA或化学抑制剂TMN355沉默Cyclophilin A，即使在经氧化LDL暴露后，细胞的脂质摄取量也减少了65-75%。分化过程中表达的清道夫受体CD36和LOX-1的表达量显著降低（p < 0.0001）。细胞外Cyclophilin A以及其他炎症相关细胞因子如TNF-α和MCP-1的水平也显著减少。TMN 355（0.5-10 μM；3-9小时）导致Cyclophilin A蛋白表达量下降了75.9%。而TMN 355（1 μM）对6小时激活后的Cyclophilin A有抑制作用。 |
| Synonyms | 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺 |
| molecular weight | 380.8 |
| Molecular formula | C21H14ClFN2O2 |
| CAS | 1186372-20-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 40 mg/mL (105.04 mM), Sonication is recommended. |
| References | 1. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152. |