| Description | TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation. |
| Synonyms | TMC647055 Choline Hydroxide Salt (1204416-97-6 free base) |
| molecular weight | 727.91 |
| Molecular formula | C37H53N5O8S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (82.43 mM) |
| References | 1. Wang H, et al. Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC64705Biochem Cell Biol. 2016 Apr;94(2):147-58. |